Activation of parenchymal CD47 promotes renal ischemia-reperfusion injury
NM Rogers, AW Thomson… - Journal of the American …, 2012 - journals.lww.com
Ischemia-reperfusion injury (IRI) contributes to decreased allograft function and allograft
rejection in transplanted kidneys. Thrombospondin-1 is a stress protein typically secreted in
response to hypoxia and the ligand activator for the ubiquitously expressed receptor CD47.
The function of activated CD47 in IRI remains completely unknown. Here, we found that both
CD47 and its ligand thrombospondin-1 were upregulated after renal IRI in mice. CD47-
knockout mice were protected against renal dysfunction and tubular damage, suggesting …
rejection in transplanted kidneys. Thrombospondin-1 is a stress protein typically secreted in
response to hypoxia and the ligand activator for the ubiquitously expressed receptor CD47.
The function of activated CD47 in IRI remains completely unknown. Here, we found that both
CD47 and its ligand thrombospondin-1 were upregulated after renal IRI in mice. CD47-
knockout mice were protected against renal dysfunction and tubular damage, suggesting …
